Convo with Dr. Tommy Megremis — What was Fauci saying to Rand Paul?
Dr. Tommy Megremis
I don’t know if you saw the exchange today between Rand Paul and Anthony Fauci. He mentioned a recent publication which denounced T cell cross reactivity as an explanation for herd immunity. Do you have any idea what the hell he was referring to, because I am not aware of any publication or prepublication that does not show evidence for T cell cross reactivity in Coronavirus. You should watch the whole seven minute discussion. It is nauseating. Let me know what you know.
Drew
I plan to watch it. I agree with you. The best data I have is that once a virus breaches bodily membranes and infects a cell 80% of immunity comes from TCell Immunity. Additionally, CD4 is essential to Beta Cell Antibody production. No TCell reaction then no antibody. I will watch and I will see if there is a reference to what he is talking about. I have seen some really poor studies lately and it would not surprise me if that is what he is talking about. I will let you know if I find anything.
Dr. Megremis
Please watch it, and let me know. I have seen absolutely no discussion to this effect.
Drew
I will.
Dr. Megremis
I found this paper through the physician covid website that he might be referring to. It is a little hard to grasp, but I do not think it dispels any evidence for T cell cross reactivity. See what you think.https://www.medrxiv.org/content/10.1101/2020.09.15.20188896v1.full.pdf
Drew
Thanks for sharing. I had not found this one. I am looking at this study but as I have contemplated what Fauci said to Rand Paul I feel like he was using his anger and not his analytics on the issue. Kind of an intellectual ad hominem attack…I read over my studies which show CD 4 & CD 8 cross reactivity from previous exposure to Coronavirus (cold) to “Novel Coronavirus” and it only reenforces my understanding that this is the primary reason (at least 50% of the 80%) that so many people mount effective immune response and yet still demonstrate no antibodies. Otherwise we have to start looking into magic fairies as the reason (my humor leaking in). I will continue to read the study you sent but I think the best thing I have seen is this study from Cell Press (https://www.cell.com/cell/pdf/S0092-8674(20)30610-3.pdf) which shows some nice stats. I appreciate your vigilance my friend.
I have read through the study and I agree that it does not seem to support what Fauci is saying. Maybe he did not read it but was told what it said? Anyway it seems to support a hypothesis that “immunological age” would be the factor which explains the lack of, can I say effectiveness, of the TCell response. If would have been quite interesting if they had combined their study with the results of in “over worked” immune system (cytokine storm). I would say if you combine the following: 1) High Immunological Age, which does not have to be advanced chronological age because of a metabolically/chronically sick population but maybe high Glycome Age (See Professor Gordan Lauc for Glycomic age research). 2) A cytokine storm based upon chronic metabolic illness. These 2 indicators would allow us to create a more precise predictor of who has the highest chance of a poor outcome from Covid-19.
Dr. Megremis
My contact said he reviewed the interview and Paul did not mention T cell cross reactivity, simply cross reactivity, but what other kind is there? So we found another article looking at humoral cross reactivity based on prior coronavirus infection. A French study which is poor in its conclusion because it singles out the RBD region of coronavirus to. make its claim instead of looking at homologous regions, in fact they do mention the saw cross reactivity with more homologous regions but without evidence decided it wasn’t important. Fauci was being intellectually dishonest. he has talked about T cell cross reactivity before, and he should have talked about with Rand Paul instead of trying to belittle him. https://www.medrxiv.org/content/10.1101/2020.08.14.20173393v1.full.pdf
Drew
Thanks for the link. I believe that everyone who seems to be TRYING to downplay the issue of T cell cross reactivity or just reactivity to coronavirus is making it all more complex than T cell immunology actually is. In the most basic sense the CD4 is looking at Peptides presented in the MHC on the cellular surface. These are proteins and the CD4 has the capacity to identify these as previously known or unknown peptides. Either way the CD 8 is called in to institute apoptosis. So we know that many viral proteins between Cold Coronavirus and “Novel” Coronavirus are the shared, quite simply, these cells will be marked for cell death. The previous study you referenced is quite probable a smoking gun (along with on-going metabolic chronic inflammatory disease) in answering the question as to why do some have poor outcomes…their immune system in general is damaged and not able to do it’s job. It is not that the ”Novel” Coronavirus is a SUPER VIRUS and able to go beyond the capacity of known virus.
This is becoming dumber and dumber…I think Fauci needs to remove his mask to reduce his inhalation of CO2. BTW: I have some MAJOR RESEARCH I will be putting out about this issue as well.